Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population.
Identifieur interne : 000064 ( Main/Exploration ); précédent : 000063; suivant : 000065Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population.
Auteurs : Manas K. Akmatov [Allemagne] ; Peggy Riese [Allemagne] ; Marcus May [Allemagne] ; Leonhard Jentsch [Allemagne] ; Malik W. Ahmed [Allemagne] ; Damaris Werner [Allemagne] ; Anja Rösel [Allemagne] ; Megan Tyler [Allemagne] ; Kevin Pessler [Allemagne] ; Jana Prokein [Allemagne] ; Inga Bernemann [Allemagne] ; Norman Klopp [Allemagne] ; Blair Prochnow [Allemagne] ; Stephanie Trittel [Allemagne] ; Aravind Tallam [Allemagne] ; Thomas Illig [Allemagne] ; Christoph Schindler [Allemagne] ; Carlos A. Guzmán [Allemagne] ; Frank Pessler [Allemagne]Source :
- Human vaccines & immunotherapeutics [ 2164-554X ] ; 2017.
Descripteurs français
- KwdFr :
- Allemagne (MeSH), Effets secondaires indésirables des médicaments (anatomopathologie), Effets secondaires indésirables des médicaments (épidémiologie), Enquêtes et questionnaires (MeSH), Femelle (MeSH), Grippe humaine (prévention et contrôle), Humains (MeSH), Mâle (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Sélection de patients (MeSH), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Études prospectives (MeSH).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- anatomopathologie : Effets secondaires indésirables des médicaments.
- effets indésirables : Vaccins antigrippaux.
- immunologie : Vaccins antigrippaux.
- prévention et contrôle : Grippe humaine.
- épidémiologie : Effets secondaires indésirables des médicaments.
- Allemagne, Enquêtes et questionnaires, Femelle, Humains, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Sélection de patients, Études prospectives.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Drug-Related Side Effects and Adverse Reactions (epidemiology), Drug-Related Side Effects and Adverse Reactions (pathology), Female (MeSH), Germany (MeSH), Humans (MeSH), Influenza Vaccines (administration & dosage), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Influenza, Human (prevention & control), Male (MeSH), Patient Selection (MeSH), Prospective Studies (MeSH), Surveys and Questionnaires (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , adverse effects : Influenza Vaccines.
- epidemiology : Drug-Related Side Effects and Adverse Reactions.
- chemical , immunology : Influenza Vaccines.
- pathology : Drug-Related Side Effects and Adverse Reactions.
- prevention & control : Influenza, Human.
- Aged, Aged, 80 and over, Female, Germany, Humans, Male, Patient Selection, Prospective Studies, Surveys and Questionnaires, Treatment Outcome.
Abstract
Elderly individuals have the highest burden of disease from influenza infection but also the lowest immune response to influenza vaccination. A better understanding of the host response to influenza vaccination in the elderly is therefore urgently needed. We conducted a biphasic prospective, population-based study from Dec. 2014 to May 2015 (pilot study) and Sept. 2015 to May 2016 (main study). Individuals 65-80 y of age were randomly selected from the residents' registration office in Hannover, Germany, for the pilot (n = 34) and main study (n = 200). The pilot study tested recruitment for study arms featuring 2, 4, or 5 visits/blood draws. The 5-visit (day 0, 1/3, 7, 21, 70 with respect to vaccination) study arm was selected for the main study. Both studies featured vaccination with Fluad™ (Novartis, Italy), a detailed medical history, a physical exam, recording of adverse events, completion of a questionnaire on common infections and an end-of-study questionnaire, and blood samples. Response rates in the pilot and main studies were 3.7% and 4.0%, respectively. Willingness to participate did not differ among the study arms (Fisher's exact test, p = 0.44). In both studies, there were no losses to follow-up. Compliance with study visits, blood sampling and completion of the questionnaires was very high (100%, >97%, 100%, respectively), as were participants' acceptance of and satisfaction with both phases of the study. The low response rates indicate the need for optimized recruitment strategies if the study population is to be representative of the general population. Nonetheless, the complex prospective study design proved to be highly feasible.
DOI: 10.1080/21645515.2017.1299300
PubMed: 28394705
PubMed Central: PMC5512809
Affiliations:
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Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Werner, Damaris" sort="Werner, Damaris" uniqKey="Werner D" first="Damaris" last="Werner">Damaris Werner</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover 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Research Center Hannover , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Pessler, Kevin" sort="Pessler, Kevin" uniqKey="Pessler K" first="Kevin" last="Pessler">Kevin Pessler</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Prokein, Jana" sort="Prokein, Jana" uniqKey="Prokein J" first="Jana" last="Prokein">Jana Prokein</name><affiliation wicri:level="1"><nlm:affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>f Hannover Unified Biobank , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Bernemann, Inga" sort="Bernemann, Inga" uniqKey="Bernemann I" first="Inga" last="Bernemann">Inga Bernemann</name><affiliation wicri:level="1"><nlm:affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>f Hannover Unified Biobank , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name><affiliation wicri:level="1"><nlm:affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>f Hannover Unified Biobank , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Prochnow, Blair" sort="Prochnow, Blair" uniqKey="Prochnow B" first="Blair" last="Prochnow">Blair Prochnow</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation></author><author><name sortKey="Trittel, Stephanie" sort="Trittel, Stephanie" uniqKey="Trittel S" first="Stephanie" last="Trittel">Stephanie Trittel</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation></author><author><name sortKey="Tallam, Aravind" sort="Tallam, Aravind" uniqKey="Tallam A" first="Aravind" last="Tallam">Aravind Tallam</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="1"><nlm:affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>f Hannover Unified Biobank , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Schindler, Christoph" sort="Schindler, Christoph" uniqKey="Schindler C" first="Christoph" last="Schindler">Christoph Schindler</name><affiliation wicri:level="1"><nlm:affiliation>e Clinical Research Center Hannover , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>e Clinical Research Center Hannover , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Guzman, Carlos A" sort="Guzman, Carlos A" uniqKey="Guzman C" first="Carlos A" last="Guzmán">Carlos A. Guzmán</name><affiliation wicri:level="1"><nlm:affiliation>c Centre for Individualized Infection Medicine , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>c Centre for Individualized Infection Medicine , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation></author><author><name sortKey="Pessler, Frank" sort="Pessler, Frank" uniqKey="Pessler F" first="Frank" last="Pessler">Frank Pessler</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>b Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>b Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Centre for Individualized Infection Medicine , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>c Centre for Individualized Infection Medicine , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28394705</idno><idno type="pmid">28394705</idno><idno type="doi">10.1080/21645515.2017.1299300</idno><idno type="pmc">PMC5512809</idno><idno type="wicri:Area/Main/Corpus">000059</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000059</idno><idno type="wicri:Area/Main/Curation">000059</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000059</idno><idno type="wicri:Area/Main/Exploration">000059</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population.</title><author><name sortKey="Akmatov, Manas K" sort="Akmatov, Manas K" uniqKey="Akmatov M" first="Manas K" last="Akmatov">Manas K. Akmatov</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>b Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>b Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Centre for Individualized Infection Medicine , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>c Centre for Individualized Infection Medicine , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Riese, Peggy" sort="Riese, Peggy" uniqKey="Riese P" first="Peggy" last="Riese">Peggy Riese</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation></author><author><name sortKey="May, Marcus" sort="May, Marcus" uniqKey="May M" first="Marcus" last="May">Marcus May</name><affiliation wicri:level="1"><nlm:affiliation>e Clinical Research Center Hannover , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>e Clinical Research Center Hannover , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Jentsch, Leonhard" sort="Jentsch, Leonhard" uniqKey="Jentsch L" first="Leonhard" last="Jentsch">Leonhard Jentsch</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Malik W" sort="Ahmed, Malik W" uniqKey="Ahmed M" first="Malik W" last="Ahmed">Malik W. Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Werner, Damaris" sort="Werner, Damaris" uniqKey="Werner D" first="Damaris" last="Werner">Damaris Werner</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Rosel, Anja" sort="Rosel, Anja" uniqKey="Rosel A" first="Anja" last="Rösel">Anja Rösel</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Tyler, Megan" sort="Tyler, Megan" uniqKey="Tyler M" first="Megan" last="Tyler">Megan Tyler</name><affiliation wicri:level="1"><nlm:affiliation>e Clinical Research Center Hannover , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>e Clinical Research Center Hannover , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Pessler, Kevin" sort="Pessler, Kevin" uniqKey="Pessler K" first="Kevin" last="Pessler">Kevin Pessler</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Prokein, Jana" sort="Prokein, Jana" uniqKey="Prokein J" first="Jana" last="Prokein">Jana Prokein</name><affiliation wicri:level="1"><nlm:affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>f Hannover Unified Biobank , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Bernemann, Inga" sort="Bernemann, Inga" uniqKey="Bernemann I" first="Inga" last="Bernemann">Inga Bernemann</name><affiliation wicri:level="1"><nlm:affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>f Hannover Unified Biobank , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Klopp, Norman" sort="Klopp, Norman" uniqKey="Klopp N" first="Norman" last="Klopp">Norman Klopp</name><affiliation wicri:level="1"><nlm:affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>f Hannover Unified Biobank , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Prochnow, Blair" sort="Prochnow, Blair" uniqKey="Prochnow B" first="Blair" last="Prochnow">Blair Prochnow</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation></author><author><name sortKey="Trittel, Stephanie" sort="Trittel, Stephanie" uniqKey="Trittel S" first="Stephanie" last="Trittel">Stephanie Trittel</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation></author><author><name sortKey="Tallam, Aravind" sort="Tallam, Aravind" uniqKey="Tallam A" first="Aravind" last="Tallam">Aravind Tallam</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation wicri:level="1"><nlm:affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>f Hannover Unified Biobank , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Schindler, Christoph" sort="Schindler, Christoph" uniqKey="Schindler C" first="Christoph" last="Schindler">Christoph Schindler</name><affiliation wicri:level="1"><nlm:affiliation>e Clinical Research Center Hannover , Hannover Medical School , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>e Clinical Research Center Hannover , Hannover Medical School , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author><author><name sortKey="Guzman, Carlos A" sort="Guzman, Carlos A" uniqKey="Guzman C" first="Carlos A" last="Guzmán">Carlos A. Guzmán</name><affiliation wicri:level="1"><nlm:affiliation>c Centre for Individualized Infection Medicine , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>c Centre for Individualized Infection Medicine , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation></author><author><name sortKey="Pessler, Frank" sort="Pessler, Frank" uniqKey="Pessler F" first="Frank" last="Pessler">Frank Pessler</name><affiliation wicri:level="1"><nlm:affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>b Helmholtz Centre for Infection Research , Braunschweig , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>b Helmholtz Centre for Infection Research , Braunschweig </wicri:regionArea><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion><wicri:noRegion>Braunschweig </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Centre for Individualized Infection Medicine , Hannover , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>c Centre for Individualized Infection Medicine , Hannover </wicri:regionArea><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion><wicri:noRegion>Hannover </wicri:noRegion></affiliation></author></analytic><series><title level="j">Human vaccines & immunotherapeutics</title><idno type="eISSN">2164-554X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Drug-Related Side Effects and Adverse Reactions (epidemiology)</term><term>Drug-Related Side Effects and Adverse Reactions (pathology)</term><term>Female (MeSH)</term><term>Germany (MeSH)</term><term>Humans (MeSH)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Male (MeSH)</term><term>Patient Selection (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Surveys and Questionnaires (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (MeSH)</term><term>Effets secondaires indésirables des médicaments (anatomopathologie)</term><term>Effets secondaires indésirables des médicaments (épidémiologie)</term><term>Enquêtes et questionnaires (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (prévention et contrôle)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Sélection de patients (MeSH)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Germany</term><term>Humans</term><term>Male</term><term>Patient Selection</term><term>Prospective Studies</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allemagne</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Sélection de patients</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Elderly individuals have the highest burden of disease from influenza infection but also the lowest immune response to influenza vaccination. A better understanding of the host response to influenza vaccination in the elderly is therefore urgently needed. We conducted a biphasic prospective, population-based study from Dec. 2014 to May 2015 (pilot study) and Sept. 2015 to May 2016 (main study). Individuals 65-80 y of age were randomly selected from the residents' registration office in Hannover, Germany, for the pilot (n = 34) and main study (n = 200). The pilot study tested recruitment for study arms featuring 2, 4, or 5 visits/blood draws. The 5-visit (day 0, 1/3, 7, 21, 70 with respect to vaccination) study arm was selected for the main study. Both studies featured vaccination with Fluad™ (Novartis, Italy), a detailed medical history, a physical exam, recording of adverse events, completion of a questionnaire on common infections and an end-of-study questionnaire, and blood samples. Response rates in the pilot and main studies were 3.7% and 4.0%, respectively. Willingness to participate did not differ among the study arms (Fisher's exact test, p = 0.44). In both studies, there were no losses to follow-up. Compliance with study visits, blood sampling and completion of the questionnaires was very high (100%, >97%, 100%, respectively), as were participants' acceptance of and satisfaction with both phases of the study. The low response rates indicate the need for optimized recruitment strategies if the study population is to be representative of the general population. Nonetheless, the complex prospective study design proved to be highly feasible.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28394705</PMID><DateCompleted><Year>2018</Year><Month>03</Month><Day>14</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2164-554X</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>7</Issue><PubDate><Year>2017</Year><Month>07</Month><Day>03</Day></PubDate></JournalIssue><Title>Human vaccines & immunotherapeutics</Title><ISOAbbreviation>Hum Vaccin Immunother</ISOAbbreviation></Journal><ArticleTitle>Establishment of a cohort for deep phenotyping of the immune response to influenza vaccination among elderly individuals recruited from the general population.</ArticleTitle><Pagination><MedlinePgn>1630-1639</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/21645515.2017.1299300</ELocationID><Abstract><AbstractText>Elderly individuals have the highest burden of disease from influenza infection but also the lowest immune response to influenza vaccination. A better understanding of the host response to influenza vaccination in the elderly is therefore urgently needed. We conducted a biphasic prospective, population-based study from Dec. 2014 to May 2015 (pilot study) and Sept. 2015 to May 2016 (main study). Individuals 65-80 y of age were randomly selected from the residents' registration office in Hannover, Germany, for the pilot (n = 34) and main study (n = 200). The pilot study tested recruitment for study arms featuring 2, 4, or 5 visits/blood draws. The 5-visit (day 0, 1/3, 7, 21, 70 with respect to vaccination) study arm was selected for the main study. Both studies featured vaccination with Fluad™ (Novartis, Italy), a detailed medical history, a physical exam, recording of adverse events, completion of a questionnaire on common infections and an end-of-study questionnaire, and blood samples. Response rates in the pilot and main studies were 3.7% and 4.0%, respectively. Willingness to participate did not differ among the study arms (Fisher's exact test, p = 0.44). In both studies, there were no losses to follow-up. Compliance with study visits, blood sampling and completion of the questionnaires was very high (100%, >97%, 100%, respectively), as were participants' acceptance of and satisfaction with both phases of the study. The low response rates indicate the need for optimized recruitment strategies if the study population is to be representative of the general population. Nonetheless, the complex prospective study design proved to be highly feasible.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Akmatov</LastName><ForeName>Manas K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Helmholtz Centre for Infection Research , Braunschweig , Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Centre for Individualized Infection Medicine , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riese</LastName><ForeName>Peggy</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>May</LastName><ForeName>Marcus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>e Clinical Research Center Hannover , Hannover Medical School , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jentsch</LastName><ForeName>Leonhard</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Malik W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Werner</LastName><ForeName>Damaris</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rösel</LastName><ForeName>Anja</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tyler</LastName><ForeName>Megan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>e Clinical Research Center Hannover , Hannover Medical School , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pessler</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prokein</LastName><ForeName>Jana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernemann</LastName><ForeName>Inga</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klopp</LastName><ForeName>Norman</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prochnow</LastName><ForeName>Blair</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trittel</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tallam</LastName><ForeName>Aravind</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Illig</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>f Hannover Unified Biobank , Hannover Medical School , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schindler</LastName><ForeName>Christoph</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>e Clinical Research Center Hannover , Hannover Medical School , Hannover , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guzmán</LastName><ForeName>Carlos A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>c Centre for Individualized Infection Medicine , Hannover , Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>d Department of Vaccinology and Applied Microbiology , Helmholtz Centre for Infection Research , Braunschweig , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pessler</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>a TWINCORE, Centre for Experimental and Clinical Infection Research , Hannover , Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Helmholtz Centre for Infection Research , Braunschweig , Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Centre for Individualized Infection Medicine , Hannover , Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Hum Vaccin Immunother</MedlineTA><NlmUniqueID>101572652</NlmUniqueID><ISSNLinking>2164-5515</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C478243">fluad vaccine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064420" MajorTopicYN="N">Drug-Related Side Effects and Adverse Reactions</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018579" MajorTopicYN="N">Patient Selection</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Germany</Keyword><Keyword MajorTopicYN="Y">elderly</Keyword><Keyword MajorTopicYN="Y">feasibility</Keyword><Keyword MajorTopicYN="Y">influenza vaccination</Keyword><Keyword MajorTopicYN="Y">nonresponse bias</Keyword><Keyword MajorTopicYN="Y">pilot study</Keyword><Keyword MajorTopicYN="Y">population-based study</Keyword><Keyword MajorTopicYN="Y">response rate</Keyword><Keyword MajorTopicYN="Y">vaccinomics</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>4</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>3</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>4</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28394705</ArticleId><ArticleId IdType="doi">10.1080/21645515.2017.1299300</ArticleId><ArticleId IdType="pmc">PMC5512809</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>AMIA Jt Summits Transl Sci Proc. 2013 Mar 18;2013:6-8</Citation><ArticleIdList><ArticleId IdType="pubmed">24303286</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Med Res Methodol. 2017 Feb 2;17 (1):18</Citation><ArticleIdList><ArticleId IdType="pubmed">28148221</ArticleId></ArticleIdList></Reference><Reference><Citation>Biopreserv Biobank. 2012 Aug;10(4):366-74</Citation><ArticleIdList><ArticleId IdType="pubmed">24849886</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Epidemiol. 2003;18(10 ):929-31</Citation><ArticleIdList><ArticleId IdType="pubmed">14598921</ArticleId></ArticleIdList></Reference><Reference><Citation>Euro Surveill. 2015 Feb 26;20(8):null</Citation><ArticleIdList><ArticleId IdType="pubmed">25742433</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Geriatr. 2016 Jan 19;16:21</Citation><ArticleIdList><ArticleId IdType="pubmed">26787444</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 Feb 20;24(8):1159-69</Citation><ArticleIdList><ArticleId IdType="pubmed">16213065</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Epidemiol. 2013 Aug;42(4):1016-7</Citation><ArticleIdList><ArticleId IdType="pubmed">24062289</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Public Health. 2015 Oct 05;15:1017</Citation><ArticleIdList><ArticleId IdType="pubmed">26438148</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Top Microbiol Immunol. 2009;333:43-82</Citation><ArticleIdList><ArticleId IdType="pubmed">19768400</ArticleId></ArticleIdList></Reference><Reference><Citation>Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1264-9</Citation><ArticleIdList><ArticleId IdType="pubmed">25293889</ArticleId></ArticleIdList></Reference><Reference><Citation>Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 May;56(5-6):845-57</Citation><ArticleIdList><ArticleId IdType="pubmed">23703506</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Epidemiol. 2006 Feb 1;163(3):197-203</Citation><ArticleIdList><ArticleId IdType="pubmed">16339049</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Immunol. 2014 Aug;29:38-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24769424</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2006 Nov 1;194 Suppl 2:S82-91</Citation><ArticleIdList><ArticleId IdType="pubmed">17163394</ArticleId></ArticleIdList></Reference><Reference><Citation>Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1300-7</Citation><ArticleIdList><ArticleId IdType="pubmed">25293885</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Public Health. 2015 Jul 07;15:618</Citation><ArticleIdList><ArticleId IdType="pubmed">26148480</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ Open. 2015 Aug 21;5(8):e007461</Citation><ArticleIdList><ArticleId IdType="pubmed">26297358</ArticleId></ArticleIdList></Reference><Reference><Citation>IRB. 2016 Mar-Apr;38(2):15-9</Citation><ArticleIdList><ArticleId IdType="pubmed">27188032</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2012 May;54(10):1427-36</Citation><ArticleIdList><ArticleId IdType="pubmed">22495079</ArticleId></ArticleIdList></Reference><Reference><Citation>Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Nov;57(11):1255-63</Citation><ArticleIdList><ArticleId IdType="pubmed">25293886</ArticleId></ArticleIdList></Reference><Reference><Citation>AJOB Empir Bioeth. 2014;5(4):14-21</Citation><ArticleIdList><ArticleId IdType="pubmed">25419533</ArticleId></ArticleIdList></Reference><Reference><Citation>Cad Saude Publica. 2015 Nov;31(11):2259-74</Citation><ArticleIdList><ArticleId IdType="pubmed">26840808</ArticleId></ArticleIdList></Reference><Reference><Citation>Cochrane Database Syst Rev. 2009 Jul 08;(3):MR000008</Citation><ArticleIdList><ArticleId IdType="pubmed">19588449</ArticleId></ArticleIdList></Reference><Reference><Citation>J Community Genet. 2013 Oct;4(4):469-82</Citation><ArticleIdList><ArticleId IdType="pubmed">23794263</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2013 Dec 5;31(50):6030-3</Citation><ArticleIdList><ArticleId IdType="pubmed">24095882</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Vaccin. 2011 Dec;7(12):1317-25</Citation><ArticleIdList><ArticleId IdType="pubmed">22108034</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Akmatov, Manas K" sort="Akmatov, Manas K" uniqKey="Akmatov M" first="Manas K" last="Akmatov">Manas K. Akmatov</name></noRegion><name sortKey="Ahmed, Malik W" sort="Ahmed, Malik W" uniqKey="Ahmed M" first="Malik W" last="Ahmed">Malik W. Ahmed</name><name sortKey="Akmatov, Manas K" sort="Akmatov, Manas K" uniqKey="Akmatov M" first="Manas K" last="Akmatov">Manas K. Akmatov</name><name sortKey="Akmatov, Manas K" sort="Akmatov, Manas K" uniqKey="Akmatov M" first="Manas K" last="Akmatov">Manas K. Akmatov</name><name sortKey="Bernemann, Inga" sort="Bernemann, Inga" uniqKey="Bernemann I" first="Inga" last="Bernemann">Inga Bernemann</name><name sortKey="Guzman, Carlos A" sort="Guzman, Carlos A" uniqKey="Guzman C" first="Carlos A" last="Guzmán">Carlos A. Guzmán</name><name sortKey="Guzman, Carlos A" sort="Guzman, Carlos A" uniqKey="Guzman C" first="Carlos A" last="Guzmán">Carlos A. 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